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(CC) Image: David E. Volk
cefaclor (cephaclor)
IUPAC name: see chemistry section
Synonyms: cephaclor
Formula: C15H14ClN3O4S

 Uses: antibiotic drug

 Properties: beta-lactam

 Hazards: see drug interactions

Mass (g/mol): CAS #:
367.8074 53994-73-3

Cefaclor, also spelled as cephaclor, is a semisynthetic broad-spectrum antibiotic drug used to treat a variety of bacterial infections. It is a second generation cephalosporin antibiotic with similar activities. It is similar in structure to cephalexin and is also similar to penicillin-like drugs because it contains a beta-lactam moiety which binds to and interferes with bacterial cell wall synthesis. It can be used to treat a wide variety of both Gram-positive and Gram-negative aerobic bacteria.

Mechanism of action

Because cefaclor is a beta-lactam-based antibiotic, it binds to specific penicillin-binding proteins located inside the bacterial cell wall and inhibits the final stage of bacterial cell wall synthesis. As a consequence of the defective cell walls, the bacteria cells are autolysed by autolysins, autolytic enzymes. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.

Susceptible microbes

Among the Gram-positive bacteria, cefaclor has shown activity against Staphylococci, including coagulase-(±) and penicillinase (+) strains, Streptococcus pneumoniae, and Streptococcus pyogenes. Among the Gram-negative aerobes, cefaclor is active against Escherichia coli, Haemophilus influenzae, including ß-lactamase-producing ampicillin-resistant strains), Klebsiella sp, and Proteus mirabilis.


The IUPAC chemical name for cefaclor is (6R,7R)-7-[(2-amino-2-phenylacetyl)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, and it has chemical formula C15H14ClN3O4S giving it a molecular mass of 367.8074 g/mol.

Synonyms and brand names


  • CCL
  • Cefaclor anhydrous
  • Cefaclorum (Latin)
  • Cephaclor

Brand names

  • Alenfral
  • Alfacet
  • Alfatil
  • Ceclor
  • Ceclor CD
  • Distaclor
  • Kefral
  • Panacef
  • Panoral
  • Raniclor

External links

The most up-to-date information about Cefaclor and other drugs can be found at the following sites.